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Lignocaine Injection belongs to two groups of medicines known as local anaesthetics and antiarrhythmic drugs. Local anaesthetics stop pain and feeling in the area around where it is injected; and antiarrhythmic drugs work by restoring irregular and/or rapid heart beats to normal. Lignocaine Injection may be used for the management of other conditions that are not mentioned above. Your doctor will be able to tell you about the specific condition for which you have been prescribed Lignocaine Injection.
Lignocaine hydrochloride is used to treat disturbances in the heart's rhythm. The pumping action of the heart is controlled by electrical impulses that are under the control of the nervous system. If the pumping action of the heart is seriously disturbed, this affects the ability of the heart to pump blood effectively around the body. Lignocaine hydrochloride acts by decreasing the sensitivity of heart muscle to electrical impulses. This slows the conduction of electrical signals in the heart muscle, which in turn, helps to restore a regular heart rhythm. This enables the heart to pump blood effectively around the body.
Patients with compromised cardiac function (e.g. congestive heart failure, cardiogenic shock) may require smaller bolus doses.Intravenous infusion is indicated in patients in whom arrhythmia tends to recur after a single injection, and who are not eligible for oral antiarrhythmic therapy.Local Anaesthesia:
*The lowest dose needed to provide effective anaesthesia should be used, and this varies depending upon area of infiltration.
*Injection should be made slowly and with frequent aspiration to guard against intravascular injection, which may produce toxic effects.Adults:
*The dose should be no greater than 200 mg.
*For spinal anaesthesia, the dose should be no greater than 100 mg.Children:
*The dose should not exceed 3mg/kgIntravenous Use in Cardiac ArrhythmiasAdults: *The usual dose is lignocaine 50 to 100 mg administered intravenously under ECG monitoring. The dose may be injected at a rate of approximately 25 to 50 mg (2.5 to 5.0 mL of the lignocaine 1% solution or 1.25 to 2.5 mL of the 2% solution) per minute.
*if the initial dose of 50 to 100 mg does not produce the desired response, a second dose may be given after five minutes. No more than 200 to 300 mg of lignocaine should be administered during a one hour period.
*intravenous infusions of lignocaine may be administered at a rate of 1 to 4 mg/minute (20 to 50 mcg/kg/minute). Intravenous infusions must be given under ECG monitoring to avoid potential overdosage and toxicity. The infusion should be terminated as soon as the patient's cardiac rhythm appears to be stable or at the earliest signs of toxicity.Children:
*A suggested paediatric dose is a loading dose of lignocaine 0.5 to 1 mg/kg repeated if necessary up to 3 to 5 mg/kg, followed by continuous infusions of 10 to 50 microgram/kg/minute.Elderly:
*dose may need to be adjusted depending on age and comorbidities.
Common side effects
This type of medication can sometimes produce toxic effects such as: lightheadedness drowsiness dizziness apprehension euphoria tinnitus blurred or double vision nystagmus vomiting sensations of heat cold or numbness twitching and tremors disorientation confusion psychosis nervousness agitation nausea difficulty swallowing dyspnoea slurred speech
When you must not be given it
Do not use Lignocaine Injection if: *You have an allergy to lignocaine or any of the ingredients listed at the end of this leaflet. Symptoms of an allergic reaction may include shortness of breath, wheezing or difficulty breathing, swelling of the face, lips, tongue or other parts of the body, rash, itching or hives on the skin. *you have an infection or swelling where the injection will be given *you have blood infections or disorders *you are in severe shock *you have low blood pressure *you have diseases of the brain and spinal cord *you have sudden frequent episodes of loss of consciousness *you have myasthenia gravis, a severe muscle weakness *you have certain heart problems
If you are not sure whether any of these apply to you, check with your doctor.
Before you are given it
Tell your doctor if: 1. you have any allergies to:
*any other medicine *any other substances, such as foods, preservatives or dyes
2. you are pregnant or intend to become pregnant
3. you are breast-feeding or plan to breast feed
4. you have or have had any medical conditions, especially the following:
*liver and/or kidney problems *epilepsy *diseases of the brain and spinal cord *heart problems *severe fever *problems with your blood pressure or circulation *slow heart beat *low potassium level *breathing difficulties *low oxygen in blood *problems with the clotting of your blood